GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs6087771 | 1 | rs6121172 | chr20:30296095 | COX4I2 | chr20:30225691-30232800:+ | 0.22 | 4.59 | 6.11E-6 | Subcortical brain region volumes |
| BLCA | cis | rs6087771 | 1 | rs6121243 | chr20:30415094 | COX4I2 | chr20:30225691-30232800:+ | 0.2 | 4.18 | 3.63E-5 | Subcortical brain region volumes |
| BLCA | cis | rs7714584 | 1 | rs61270113 | chr5:150226263 | LOC134466 | chr5:150310000-150326146:- | 0.43 | 5.25 | 2.55E-7 | Crohn's disease |
| BLCA | cis | rs12748152 | 1 | rs61457762 | chr1:27284157 | GPN2 | chr1:27205873-27216869:- | 0.47 | 4.05 | 6.12E-5 | HDL cholesterol;Triglycerides;LDL cholesterol |
| BLCA | cis | rs6151429 | 1 | rs6151429 | chr22:51063477 | ARSA | chr22:51063450-51066607:- | -0.92 | -9.21 | 2.14E-18 | Blood metabolite levels |
| BLCA | cis | rs61524473 | 1 | rs61524473 | chr15:45646283 | SPATA5L1 | chr15:45694519-45713614:+ | 0.34 | 4.86 | 1.7E-6 | Metabolite levels (small molecules and protein measures) |
| BLCA | cis | rs7714584 | 1 | rs61530785 | chr5:150261364 | LOC134466 | chr5:150310000-150326146:- | 0.55 | 7.03 | 9.29E-12 | Crohn's disease |
| BLCA | cis | rs9815354 | 1 | rs61744385 | chr3:41756986 | ULK4 | chr3:41288091-42003660:- | 0.67 | 10.35 | 2.66E-22 | Diastolic blood pressure |
| BLCA | cis | rs9815354 | 1 | rs61744388 | chr3:41756965 | ULK4 | chr3:41288091-42003660:- | 0.67 | 10.35 | 2.66E-22 | Diastolic blood pressure |
| BLCA | cis | rs2275426 | 1 | rs61783200 | chr1:46297403 | CCDC163P | chr1:45960581-45965646:- | -0.37 | -7 | 1.18E-11 | Body mass index |
| BLCA | cis | rs2275426 | 1 | rs61783220 | chr1:46335312 | CCDC163P | chr1:45960581-45965646:- | -0.37 | -7 | 1.18E-11 | Body mass index |
| BLCA | cis | rs11723261 | 1 | rs61792114 | chr4:289139 | ZNF718 | chr4:53272-156488:+ | 0.32 | 4.53 | 7.98E-6 | Immune response to smallpox vaccine (IL-6) |
| BLCA | cis | rs11723261 | 1 | rs61792116 | chr4:301077 | ZNF718 | chr4:53272-156488:+ | 0.35 | 4.65 | 4.63E-6 | Immune response to smallpox vaccine (IL-6) |
| BLCA | cis | rs11723261 | 1 | rs61794996 | chr4:209328 | ZNF718 | chr4:53272-156488:+ | 0.34 | 4.46 | 1.06E-5 | Immune response to smallpox vaccine (IL-6) |
| BLCA | cis | rs11723261 | 1 | rs61794997 | chr4:222103 | ZNF718 | chr4:53272-156488:+ | 0.34 | 4.49 | 9.44E-6 | Immune response to smallpox vaccine (IL-6) |